Caring for legs that swell, bruise easily and hurt to the touch is not just about losing weight, dieting, or getting massages. This condition requires proper attention, consistency, and early action.
Scientific studies on swollen legs, unexplained bruising, pain to the touch and lymphatic system health.
(1) Herbst KL. Rare adipose tissue disorders that can be confused with obesity, including lipedema. Acta Pharmacologica Sinica – 2012
(2) International Society of Lymphology. Diagnosis and treatment of peripheral lymphedema. Consensus document – 2003
(3) Schook CC, et al. Differential diagnosis of lower-extremity enlargement in pediatric patients referred with a diagnosis of lymphedema. Plastic and Reconstructive Surgery – 2011
(4) Hodson S, Eaton S. Managing lipedema: current gaps in knowledge. Journal of Lymphoedema – 2013
(5) MacDonald JM, et al. Lymphedema, lipedema, and open wounds: the role of compression therapy. Surgical Clinics of North America – 2003
(6) Lee BB, et al. Lymphedema: a concise compendium of theory and practice. Springer – 2011
(7) Szel E, et al. Pathophysiological dilemmas of lipedema. Medical Hypotheses – 2014
(8) Szolnoky G, et al. Lipedema is associated with increased aortic stiffness. Lymphology – 2012
(9) Jones D, Min W. General overview of lymphatic vessels and their emerging role in cardiovascular disease. Journal of Cardiovascular Disease Research – 2011
(10) Alexander JS, et al. Gastrointestinal lymphatics in health and disease. Pathophysiology – 2010
(11) Scallan JP, et al. Lymphatic vascular integrity is altered in type 2 diabetes by impaired nitric oxide signaling. Cardiovascular Research – 2015
(12) Kobayashi J, et al. A nitric oxide-rich diet for lifestyle-related diseases. Nutrients – 2015
(13) Tan B, et al. Regulatory roles of L-arginine in reducing white adipose tissue. Frontiers in Bioscience – 2012
(14) Morris SM Jr. Arginine metabolism: boundaries of our current knowledge. Journal of Nutrition – 2007
(15) Cani PD, et al. Involvement of gut microbiota in low-grade inflammation and type 2 diabetes associated with obesity. Gut Microbes – 2012
(16) Musso G, et al. Obesity, diabetes, and gut microbiota: expanding the hygiene hypothesis. Diabetes Care – 2010
(17) Veiga P, et al. Changes in human gut microbiota induced by a fermented dairy product. Scientific Reports – 2014
(18) Ghanim H, et al. Orange juice neutralizes the pro-inflammatory effect of a high-fat, high-carbohydrate meal. American Journal of Clinical Nutrition – 2010
(19) Deopurkar R, et al. Differential effects of cream, glucose, and orange juice on inflammation and endotoxins. Diabetes Care – 2010
(20) Basaranoglu M, et al. Carbohydrate intake and non-alcoholic fatty liver disease: fructose as a risk factor. Hepatobiliary Surgery and Nutrition – 2015
(21) Anderson EL, et al. Prevalence of non-alcoholic fatty liver disease in children and adolescents: systematic review and meta-analysis. PLOS One – 2015
(22) Green CJ, Hodson L. Influence of dietary fat on liver fat accumulation. Nutrients – 2014
(23) Wiig H, et al. Immune cells control lymphatic electrolyte homeostasis in the skin and blood pressure. Journal of Clinical Investigation – 2013
(24) Mizuno R, et al. A high-salt diet modulates the mechanical activity of collecting lymphatic vessels. Lymphatic Research and Biology – 2015
<
